Middle East Respiratory Syndrome
Identifieur interne : 000777 ( Main/Exploration ); précédent : 000776; suivant : 000778Middle East Respiratory Syndrome
Auteurs : Yaseen M. Arabi ; Hanan H. Balkhy ; Frederick G. Hayden ; Abderrezak Bouchama ; Thomas Luke ; J. Kenneth Baillie ; Awad Al-Omari ; Ali H. Hajeer ; Mikiko Senga ; Mark R. Denison ; Jonathan S. Nguyen-Van-Tam ; Nahoko Shindo ; Alison Bermingham ; James D. Chappell ; Maria D. Van Kerkhove ; Robert A. FowlerSource :
- The New England journal of medicine [ 0028-4793 ] ; 2017.
Abstract
Between September 2012 and January 20, 2017, the World Health Organization (WHO) received reports from 27 countries of 1879 laboratory-confirmed cases in humans of the Middle East respiratory syndrome (MERS) caused by infection with the MERS coronavirus (MERS-CoV) and at least 659 related deaths. Cases of MERS-CoV infection continue to occur, including sporadic zoonotic infections in humans across the Arabian Peninsula, occasional importations and associated clusters in other regions, and outbreaks of nonsustained human-to-human transmission in health care settings. Dromedary camels are considered to be the most likely source of animal-to-human transmission. MERS-CoV enters host cells after binding the dipeptidyl peptidase 4 (DPP-4) receptor and the carcinoembryonic antigen–related cell-adhesion molecule 5 (CEACAM5) cofactor ligand, and it replicates efficiently in the human respiratory epithelium. Illness begins after an incubation period of 2 to 14 days and frequently results in hypoxemic respiratory failure and the need for multiorgan support. However, asymptomatic and mild cases also occur. Real-time reverse-transcription–polymerase-chain-reaction (RT-PCR) testing of respiratory secretions is the mainstay for diagnosis, and samples from the lower respiratory tract have the greatest yield among seriously ill patients. There is no antiviral therapy of proven efficacy, and thus treatment remains largely supportive; potential vaccines are at an early developmental stage. There are multiple gaps in knowledge regarding the evolution and transmission of the virus, disease pathogenesis, treatment, and prospects for a vaccine. The ongoing occurrence of MERS in humans and the associated high mortality call for a continued collaborative approach toward gaining a better understanding of the infection both in humans and in animals.
MERS-CoV was first identified in September 2012
Url:
DOI: 10.1056/NEJMsr1408795
PubMed: 28177862
PubMed Central: 5362064
Affiliations:
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Le document en format XML
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<author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name>
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<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
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<author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name>
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<author><name sortKey="Bouchama, Abderrezak" sort="Bouchama, Abderrezak" uniqKey="Bouchama A" first="Abderrezak" last="Bouchama">Abderrezak Bouchama</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East Respiratory Syndrome</title>
<author><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name>
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<author><name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
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<author><name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name>
</author>
<author><name sortKey="Bouchama, Abderrezak" sort="Bouchama, Abderrezak" uniqKey="Bouchama A" first="Abderrezak" last="Bouchama">Abderrezak Bouchama</name>
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<author><name sortKey="Luke, Thomas" sort="Luke, Thomas" uniqKey="Luke T" first="Thomas" last="Luke">Thomas Luke</name>
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<author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J. Kenneth" last="Baillie">J. Kenneth Baillie</name>
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<author><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name>
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<author><name sortKey="Hajeer, Ali H" sort="Hajeer, Ali H" uniqKey="Hajeer A" first="Ali H." last="Hajeer">Ali H. Hajeer</name>
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<author><name sortKey="Senga, Mikiko" sort="Senga, Mikiko" uniqKey="Senga M" first="Mikiko" last="Senga">Mikiko Senga</name>
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<author><name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name>
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<author><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name>
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<author><name sortKey="Shindo, Nahoko" sort="Shindo, Nahoko" uniqKey="Shindo N" first="Nahoko" last="Shindo">Nahoko Shindo</name>
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<author><name sortKey="Bermingham, Alison" sort="Bermingham, Alison" uniqKey="Bermingham A" first="Alison" last="Bermingham">Alison Bermingham</name>
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<author><name sortKey="Chappell, James D" sort="Chappell, James D" uniqKey="Chappell J" first="James D." last="Chappell">James D. Chappell</name>
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<author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name>
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<author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name>
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<series><title level="j">The New England journal of medicine</title>
<idno type="ISSN">0028-4793</idno>
<idno type="eISSN">1533-4406</idno>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p id="P1">Between September 2012 and January 20, 2017, the World Health
Organization (WHO) received reports from 27 countries of 1879
laboratory-confirmed cases in humans of the Middle East respiratory syndrome
(MERS) caused by infection with the MERS coronavirus (MERS-CoV) and at least 659
related deaths. Cases of MERS-CoV infection continue to occur, including
sporadic zoonotic infections in humans across the Arabian Peninsula, occasional
importations and associated clusters in other regions, and outbreaks of
nonsustained human-to-human transmission in health care settings. Dromedary
camels are considered to be the most likely source of animal-to-human
transmission. MERS-CoV enters host cells after binding the dipeptidyl peptidase
4 (DPP-4) receptor and the carcinoembryonic antigen–related cell-adhesion
molecule 5 (CEACAM5) cofactor ligand, and it replicates efficiently in the human
respiratory epithelium. Illness begins after an incubation period of 2 to 14
days and frequently results in hypoxemic respiratory failure and the need for
multiorgan support. However, asymptomatic and mild cases also occur. Real-time
reverse-transcription–polymerase-chain-reaction (RT-PCR) testing of
respiratory secretions is the mainstay for diagnosis, and samples from the lower
respiratory tract have the greatest yield among seriously ill patients. There is
no antiviral therapy of proven efficacy, and thus treatment remains largely
supportive; potential vaccines are at an early developmental stage. There are
multiple gaps in knowledge regarding the evolution and transmission of the
virus, disease pathogenesis, treatment, and prospects for a vaccine. The ongoing
occurrence of MERS in humans and the associated high mortality call for a
continued collaborative approach toward gaining a better understanding of the
infection both in humans and in animals.</p>
<p id="P2">MERS-CoV was first identified in September 2012<xref rid="R1" ref-type="bibr">1</xref>
in a patient from Saudi Arabia who had hypoxemic
respiratory failure and multiorgan illness. Subsequent cases have included
infections in humans across the Arabian Peninsula, occasional importations and
associated clusters in other regions, and outbreaks of nonsustained
human-to-human transmission in health care settings (<xref ref-type="fig" rid="F1">Fig. 1</xref>
).</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Al Omari, Awad" sort="Al Omari, Awad" uniqKey="Al Omari A" first="Awad" last="Al-Omari">Awad Al-Omari</name>
<name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name>
<name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J. Kenneth" last="Baillie">J. Kenneth Baillie</name>
<name sortKey="Balkhy, Hanan H" sort="Balkhy, Hanan H" uniqKey="Balkhy H" first="Hanan H." last="Balkhy">Hanan H. Balkhy</name>
<name sortKey="Bermingham, Alison" sort="Bermingham, Alison" uniqKey="Bermingham A" first="Alison" last="Bermingham">Alison Bermingham</name>
<name sortKey="Bouchama, Abderrezak" sort="Bouchama, Abderrezak" uniqKey="Bouchama A" first="Abderrezak" last="Bouchama">Abderrezak Bouchama</name>
<name sortKey="Chappell, James D" sort="Chappell, James D" uniqKey="Chappell J" first="James D." last="Chappell">James D. Chappell</name>
<name sortKey="Denison, Mark R" sort="Denison, Mark R" uniqKey="Denison M" first="Mark R." last="Denison">Mark R. Denison</name>
<name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A." last="Fowler">Robert A. Fowler</name>
<name sortKey="Hajeer, Ali H" sort="Hajeer, Ali H" uniqKey="Hajeer A" first="Ali H." last="Hajeer">Ali H. Hajeer</name>
<name sortKey="Hayden, Frederick G" sort="Hayden, Frederick G" uniqKey="Hayden F" first="Frederick G." last="Hayden">Frederick G. Hayden</name>
<name sortKey="Luke, Thomas" sort="Luke, Thomas" uniqKey="Luke T" first="Thomas" last="Luke">Thomas Luke</name>
<name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name>
<name sortKey="Senga, Mikiko" sort="Senga, Mikiko" uniqKey="Senga M" first="Mikiko" last="Senga">Mikiko Senga</name>
<name sortKey="Shindo, Nahoko" sort="Shindo, Nahoko" uniqKey="Shindo N" first="Nahoko" last="Shindo">Nahoko Shindo</name>
<name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name>
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